Acid production by human strains of Streptococcus mutans and Streptococcus sobrinus
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Updated: Nov 6, 2026

Generation of a Gene-disrupted Streptococcus mutans Strain Without Gene Cloning
Published on: October 23, 2017
B Köhler1, D Birkhed, S Olsson
1Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
Abstract:
Acid production by washed suspensions of human strains of Streptococcus mutans (n = 18) and Streptococcus sobrinus (n = 12) was measured. The strains were isolated from infants and adolescents with varying caries experience. Some of these strains and two laboratory strains (1 S. mutans and 1 S. sobrinus) had been tested in an earlier study for their cariogenicity in hamsters. Further, 3 Streptococcus sanguis strains and 1 S. sobrinus laboratory strain were included. Acid production was determined in repeated titration experiments at a constant pH of 5.5. Higher mean acid production activities (p < 0.05) were obtained by S. sobrinus compared with both S. mutans and S. sanguis. However, large variations among the strains were found both between and within the species. No clear relationship was found between the glycolytic activity of strains and the caries prevalence of the children from whom the strains had been isolated or the caries scores in a hamster model. In conclusion, although both S. mutans and S. sobrinus have aciduric and acidogenic properties, it is difficult to relate the acid production activity of pure cultures in vitro to the caries process in vivo.
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