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Updated: Aug 10, 2026

04:47
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
Redirection of cellular cytotoxicity. A two-step approach using recombinant single-chain Fv molecules
A J George1, J A Titus, C R Jost
1Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Abstract:
In this article the authors discuss an indirect system for redirecting cellular cytotoxicity, which utilizes a "universal" bispecific antibody to redirect T-cells to kill cells targeted with single-chain Fv (sFv) fusion proteins that carry a peptide tag recognized by the bispecific antibody. This approach has a number of theoretical advantages in the immunotherapy of cancer.

