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Biodegradable microspheres in drug delivery

H Okada1, H Toguchi

  • 1Pharmaceutical Development Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1995
PubMed
Summary

Biodegradable microspheres offer advanced drug delivery. Poly(lactic acid) and poly(lactic/glycolic acid) microspheres show promise for sustained peptide release and targeted cancer therapy.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Biodegradable polymers are crucial for advanced drug delivery systems.
  • Microsphere preparation and drug release kinetics are key considerations.
  • Understanding polymer characteristics (physicochemical properties, bioerosion, biocompatibility) is essential.

Purpose of the Study:

  • To review the general aspects of biodegradable microspheres in drug delivery.
  • To discuss the relationship between drug release patterns and pharmacological activity.
  • To highlight successful applications in sustained peptide delivery and targeted cancer therapy.

Main Methods:

  • Review of literature on biodegradable polymers and microsphere preparation.
  • Analysis of drug release mechanisms from parenteral and non-parenteral formulations.
  • Examination of clinical studies and therapeutic outcomes for specific drug-loaded microspheres.

Main Results:

  • Poly(lactic acid) (PLA) and poly(lactic/glycolic acid) (PLGA) microspheres enable sustained release of peptides like leuprorelin acetate and thyrotropin-releasing hormone (TRH).
  • Biodegradable microspheres are effective in targeted drug delivery, as demonstrated by chemoembolization using PLGA microspheres with an angiogenesis inhibitor (TNP-470) for antitumor therapy.
  • The characteristics of biodegradable polymers significantly influence drug release profiles and therapeutic efficacy.

Conclusions:

  • Biodegradable microspheres, particularly those made from PLA and PLGA, represent a versatile platform for controlled and targeted drug delivery.
  • These systems are effective for delivering therapeutic peptides and proteins, improving pharmacological activity and patient outcomes.
  • Further research into biodegradable microspheres holds significant potential for developing innovative treatments for various diseases, including cancer.

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