[Excretion of erythromycin, clindamycin and lincomycin into the saliva]

In rabbit experiments (n = 10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration. Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.