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Thyroid malignancy in multinodular goitre and solitary nodule
S A Abu-Eshy1, A R Khan, G M Khan
1Department of Surgery, Asir Central Hospital, King Saud University, Abha Branch, Saudi Arabia.
Journal of the Royal College of Surgeons of Edinburgh
|October 1, 1995
Summary
Thyroid nodules, whether solitary or multinodular goitre, show similar malignancy rates. However, malignancy is more common in females with solitary nodules and at older ages, suggesting tailored management for thyroid cancer.
Area of Science:
- Endocrinology
- Surgical Pathology
Background:
- Multinodular goitre (MNG) and solitary nodules (SN) are common thyroid conditions.
- Differentiating benign from malignant thyroid nodules is crucial for patient management.
Purpose of the Study:
- To investigate the prevalence and patterns of thyroid malignancy in patients with MNG versus SN.
- To compare malignancy rates and characteristics between MNG and SN.
Main Methods:
- Retrospective analysis of 361 thyroid specimens over a 6.5-year period.
- Statistical comparison of malignancy rates, patient demographics, and histopathological findings between MNG and SN groups.
Main Results:
- Overall malignancy rates were 8% for MNG and 15.2% for SN (P=0.06).
- Malignancy was significantly more common in females with SN compared to MNG (P=0.03).
- Thyroid carcinoma incidence was higher in SN than MNG (P=0.01).
Conclusions:
- Surgical intervention is recommended for males with MNG.
- Conservative management for females with MNG is suggested, with surgery based on clinical judgment and fine needle aspiration biopsy results.
- Solitary nodules warrant careful evaluation due to a higher incidence of carcinoma.