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bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation
C W Olsen1, J C Kehren, N R Dybdahl-Sissoko
1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706, USA.
Journal of Virology
|January 1, 1996
Abstract:
We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.