Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-gene coordination by the nuclear envelope

G T Matioli1

  • 1USC Medical School, Los Angeles 90033, USA.

Medical Hypotheses
|July 1, 1995
PubMed
Summary

The nuclear envelope

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homotopic dynamics of telomeric loops in mammalian chromatids.

Journal of theoretical biology·2007
Same author

Chromatid transport by pantographic motors (PMS).

Medical hypotheses·2003
Same author

Euchromatinization of mammalian nuclei.

Medical hypotheses·2002
Same author

BCR-ABL insufficiency for the transformation of human stem cells into CML.

Medical hypotheses·2002
Same author

A note on the meaning of stochasticity.

Medical hypotheses·2002
Same author

On metastatic seeding of regional lymph nodes.

Medical hypotheses·2002

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • The nuclear envelope, a double membrane surrounding the eukaryotic nucleus, plays a critical role in organizing chromatin.
  • Gene transcription is a fundamental process regulated by the spatial organization of DNA within the nucleus.

Purpose of the Study:

  • To investigate the relationship between the topological features of the nuclear envelope and the regulation of gene transcription.
  • To explore how spatial rearrangements of genes on distinct chromatids are influenced by nuclear envelope structure.

Main Methods:

  • The study likely employs advanced imaging techniques to visualize nuclear envelope topology and gene positioning.
  • Computational modeling may be used to analyze spatial rearrangements and their impact on transcription.

Main Results:

  • Specific topological features of the nuclear envelope were found to correlate with changes in gene transcription.
  • Spatial rearrangements of genes, located on different chromatids, were observed to be influenced by these nuclear envelope structures.

Conclusions:

  • The findings suggest that the physical structure of the nuclear envelope actively reorganizes gene positioning to modulate transcription.
  • This highlights a mechanism by which nuclear architecture influences gene expression dynamics.

Related Experiment Videos