Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural and functional analysis of pp70S6k

L Cheatham1, M Monfar, M M Chou

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02130, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 5, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Temporal Changes in Urine-based Metabolomic and Kidney Injury Markers to Detect Compound Induced Acute Kidney Tubular Toxicity in Beagle Dogs.

Current topics in medicinal chemistry·2017
Same author

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.

Cell death & disease·2014
Same author

Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2013
Same author

Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.

Oncogene·2011
Same author

TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.

Oncogene·2010
Same author

Optical system to compute intensity moments: design.

Applied optics·2010
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

The pp70/85-kDa S6 kinase (pp70S6k) regulates cell cycle progression. Structure/function analysis reveals that both N and C termini are crucial for its complex regulation by growth factors.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The pp70/85-kDa S6 kinases (pp70S6k) are key regulators of the G1 phase of the cell cycle.
  • pp70S6k controls the phosphorylation of 40S ribosomal protein S6 and the transcription factor CREM tau.
  • Upstream regulators like 1-phosphatidylinositol 3-kinase and phospholipase C are implicated, but activation mechanisms remain unclear.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of pp70S6k.
  • To understand how growth factors and rapamycin modulate pp70S6k activity.
  • To perform a structure/function analysis of pp70S6k.

Main Methods:

  • Structure/function analysis of pp70S6k.
  • Investigating the role of N and C termini in kinase activity.

Related Experiment Videos

Main Results:

  • Both the N and C termini of pp70S6k are involved in its intricate regulation.
  • This finding contributes to understanding the kinase's response to mitogenic stimuli.

Conclusions:

  • The N and C termini are critical components for the complex regulation of pp70S6k activity.
  • Further research into these domains can reveal detailed activation pathways.