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[Correlation between four-hour creatinine clearance and 51Cr-EDTA test]
Revista Medica De Chile
|May 1, 1995
Summary
A four-hour creatinine clearance test accurately estimates glomerular filtration rate (GFR). This method offers a reliable alternative to the 51Cr-EDTA test, especially for non-diabetic nephropathy patients.
Area of Science:
- Nephrology
- Clinical Chemistry
- Diagnostic Testing
Background:
- Creatinine clearance (CrCl) is a common measure of glomerular filtration rate (GFR) but is prone to errors.
- These errors include tubular creatinine secretion and inaccurate urine collection.
- The 51Cr-EDTA test is accurate but can be affected by edema, delaying radioisotope equilibrium.
Purpose of the Study:
- To validate a 4-hour creatinine clearance method.
- To assess its correlation with the established 51Cr-EDTA test for measuring GFR.
Main Methods:
- Glomerular filtration rate (GFR) was measured in 59 diabetic patients without nephropathy.
- GFR was assessed using 51Cr-EDTA with blood sampling at 10, 30, 120, and 240 minutes.
- Simultaneously, creatinine clearance was determined via a 4-hour urine collection.
Main Results:
- A strong overall correlation (r=0.85, p < 0.001) was found between the 4-hour creatinine clearance and 51Cr-EDTA methods.
- Correlations remained significant across different GFR ranges: 0.8 ( < 95 ml/min), 0.51 (95–127 ml/min), and 0.8 ( > 127 ml/min).
- The regression equation was y = 1.2x + 13, indicating good agreement.
Conclusions:
- The 4-hour creatinine clearance test is a reliable and accurate method for estimating glomerular filtration rate.
- This validated method provides a practical alternative for GFR assessment in clinical settings.