Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heat stabilized, infectious poliovirus

O Ofori-Anyinam1, R Vrijsen, P Kronenberger

  • 1Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.

Vaccine
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.

Leukemia·2013
Same author

Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1-4 in Mozambique.

Tropical medicine & international health : TM & IH·2007
Same author

The morphogenesis of Theiler's murine encephalomyelitis virus is strain specific.

Archives of virology·2003
Same author

Uptake of poliovirus into the endosomal system of HeLa cells.

Archives of virology·1998
Same author

Use of free-flow electrophoresis for the analysis of cellular uptake of picornaviruses.

Electrophoresis·1998
Same author

Major and minor receptor group human rhinoviruses penetrate from endosomes by different mechanisms.

Journal of virology·1998
Same journal

Immunity gaps for several vaccine preventable diseases in Norway.

Vaccine·2026
Same journal

Australians' attitudes to mRNA vaccination in humans and animals: A cross-sectional survey.

Vaccine·2026
Same journal

Immunoproteomics and reverse vaccinology identify a protective T-cell epitope from Fonsecaea pedrosoi for experimental chromoblastomycosis.

Vaccine·2026
Same journal

Retraction notice to "Effectiveness of prescription-based influenza vaccination services among older adults in Binzhou, China: A cluster-randomized controlled trial" [Vaccine 82 (2026) 128588].

Vaccine·2026
Same journal

Barriers and facilitators to COVID-19 vaccination programme implementation in Ireland: a qualitative study of implementation stakeholders using CFIR.

Vaccine·2026
Same journal

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine·2026
See all related articles

The antiviral pyridazinamine R78206 protected poliovirus strains from heat inactivation. This compound demonstrated potential for stabilizing polioviruses against thermal damage without significant viral loss.

Area of Science:

  • Virology
  • Antiviral drug development
  • Biochemistry

Background:

  • Polioviruses are significant human pathogens.
  • Thermal inactivation is a method to control viral infectivity.
  • Antiviral compounds are crucial for managing viral diseases.

Purpose of the Study:

  • To investigate the effect of pyridazinamine R78206 on poliovirus stability.
  • To assess the protective capacity of R78206 against thermal inactivation.
  • To determine the concentration-dependent effects of R78206 on poliovirus strains.

Main Methods:

  • Poliovirus type 1 (Mahoney) and type 3 (Sabin) were treated with R78206.
  • The antiviral compound was bound to the virus, and unbound compound removed by dialysis.
  • Treated and untreated viruses were subjected to thermal inactivation at 46°C.

Related Experiment Videos

Main Results:

  • R78206 treatment conferred protection against thermal inactivation at 46°C for both poliovirus strains.
  • No significant viral inactivation was observed due to R78206 treatment at tested concentrations.
  • A minor inactivation effect was noted for the Sabin 3 strain only at high R78206 concentrations.

Conclusions:

  • Pyridazinamine R78206 effectively stabilizes polioviruses against thermal stress.
  • R78206 shows potential as a stabilizing agent for poliovirus vaccines or research materials.
  • The compound's safety profile appears favorable, with minimal inactivation observed.