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Updated: Aug 6, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Heat stabilized, infectious poliovirus
O Ofori-Anyinam1, R Vrijsen, P Kronenberger
1Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Abstract:
Polioviruses type 1 (Mahoney) and type 3 (Sabin) were treated with the antiviral pyridazinamine R78206 by first binding the compound to the virus and then removing unbound compound by dialysis. As a result of this treatment, both poliovirus strains were protected against thermal inactivation at 46 degrees C. The R78206 treatment did not cause inactivation except with the Sabin 3 strain at high R78206 concentrations.
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