Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microsatellite instability in human cancer

M R Speicher1

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

Oncology Research
|January 1, 1995
PubMed
Summary

Microsatellite instability (MSI) is a key genetic alteration in tumorigenesis. This review details known and unknown genes involved in MSI and their role in cancer development and progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The biology of circulating tumor cells.

Oncogene·2015
Same author

Fatal EBV infection and variable clinical manifestations in an XLP-1 pedigree - rapid diagnosis of primary immunodeficiencies may save lives.

Klinische Padiatrie·2012
Same author

Predictive diagnosis of the cancer prone Li-Fraumeni syndrome by accident: new challenges through whole genome array testing.

Journal of medical genetics·2009
Same author

Two novel mutations in the GDAP1 and PRX genes in early onset Charcot-Marie-Tooth syndrome.

Neuropediatrics·2008
Same author

Towards many colors in FISH on 3D-preserved interphase nuclei.

Cytogenetic and genome research·2006
Same author

Behaviour of human heterochromatic regions during the synapsis of homologous chromosomes.

Human reproduction (Oxford, England)·2006

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Tumorigenesis research has advanced with the identification of widespread genomic alterations, notably microsatellite instability (MSI).
  • Knowledge of bacterial and yeast DNA mismatch repair genes facilitated the identification of homologous human genes linked to MSI.
  • Emerging research suggests additional, yet unidentified, genes contribute to the MSI genotype.

Purpose of the Study:

  • To review identified genes responsible for microsatellite instability.
  • To explore the role of these genes in tumorigenesis and tumor progression.
  • To detail the occurrence of microsatellite instability across various tumor types.

Main Methods:

  • Literature review of genetic alterations in cancer.
  • Analysis of DNA mismatch repair pathways.
  • Compilation of data on microsatellite instability prevalence in different cancers.

Main Results:

  • Several genes causing microsatellite instability have been identified, linked to DNA mismatch repair.
  • Microsatellite instability provides a model for mutator phenotypes, explaining mutation accumulation in cancer cells.
  • The review details the specific genes involved and their functions.

Conclusions:

  • Microsatellite instability is a significant factor in tumorigenesis and tumor progression.
  • Further research is needed to identify all genes contributing to the microsatellite instability genotype.
  • Understanding MSI genes is crucial for cancer research and treatment strategies.

Related Experiment Videos