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Stimulation and regulation of tumor cell motility in invasion and metastasis
M D Levine1, L A Liotta, M L Stracke
1Harvard College, Cambridge, MA 02138, USA.
EXS
|January 1, 1995
Abstract:
In this review, the role of extracellular factors in the stimulation and regulation of tumor cell motility are discussed. Tumor cells respond in a motile fashion to a variety of external ligands including autocrine motility factors, growth factors, and components of the extracellular matrix. Since tumor cell motility is a necessary component of tumor invasion and metastasis, we speculate that these protein factors could play important regulatory roles in tumor motility at different stages of the metastatic cascade.