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Serum enzyme changes in hot work

D J Parikh, N L Ramanathan

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |April 1, 1977
    PubMed
    Summary
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    Foundry workers and gardeners showed significantly different lactic dehydrogenase (LDH) levels compared to sedentary individuals. Enzyme activity slightly increased after exposure but was not statistically significant.

    Area of Science:

    • Occupational Health
    • Biochemistry
    • Environmental Medicine

    Background:

    • Occupational exposures can impact physiological markers.
    • Serum enzyme levels may indicate cellular stress or damage.
    • Foundry work and gardening involve distinct environmental exposures.

    Purpose of the Study:

    • To investigate serum enzyme levels in workers with different occupational exposures.
    • To compare enzyme levels (GOT, GPT, LDH, adolase) between foundry workers, gardeners, and sedentary controls.
    • To assess the impact of occupational heat and sun exposure on serum enzyme activity.

    Main Methods:

    • Medical screening of 31 foundry workers, 13 gardeners, and 16 sedentary controls.
    • Measurement of serum enzyme levels: glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactic dehydrogenase (LDH), and aldolase.

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  • Statistical comparison of enzyme levels between occupational groups and controls.

    • Main Results:

    • Significantly elevated lactic dehydrogenase (LDH) levels were observed in foundry workers and gardeners compared to sedentary subjects.
    • A non-significant trend of increased serum enzyme activity was noted post-exposure in both exposed groups.
    • No statistically significant differences were found for GOT, GPT, or aldolase levels between groups.

    Conclusions:

    • Occupational heat and sun exposure, as experienced by foundry workers and gardeners, may influence LDH levels.
    • Further research is needed to confirm the observed trends and explore the mechanisms of enzyme level changes.
    • Serum enzyme analysis can serve as a potential biomarker for occupational exposure effects.