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Mivacurium chloride administration by infusion
1Department of Anesthesia and Critical Care, University of Chicago Hospitals, IL 60637, USA.
Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1995
Summary
Mivacurium offers rapid recovery from neuromuscular blockade due to quick hydrolysis. Its predictable infusion rates and lack of cumulative effects make it ideal for infusions in adults and children.
Area of Science:
- Pharmacology
- Anesthesiology
Background:
- Neuromuscular blocking agents are essential in anesthesia.
- Mivacurium is an intermediate-acting, non-depolarizing neuromuscular blocker.
Purpose of the Study:
- To evaluate the duration of action and recovery profile of mivacurium.
- To assess the suitability of mivacurium for infusion anesthesia.
Main Methods:
- Pharmacokinetic and pharmacodynamic analysis of mivacurium.
- Titration of mivacurium infusion to maintain specific levels of neuromuscular blockade.
Main Results:
- Mivacurium exhibits rapid hydrolysis by plasma cholinesterase, leading to a short duration of action.
- Recovery from neuromuscular blockade is rapid, with 5-95% twitch recovery in 13-15 minutes.
- Infusion rates for maintaining neuromuscular blockade are approximately 6-7 mcg/kg/min in adults and 14 mcg/kg/min in children during N2O/opioid anesthesia.
- No cumulative effects of mivacurium were observed, regardless of dose or infusion duration.
Conclusions:
- Mivacurium's rapid hydrolysis and predictable recovery profile make it highly titratable.
- Its lack of cumulative effects supports its use as a suitable agent for continuous infusion during anesthesia.