[Ketamine-clofelin anesthesia in children]

Changes in the activity of the main antiradical enzymes of the blood serum--superoxide dismutase (SOD) and catalase (C), red cell peroxide resistance (RCPR), accumulation of the intermediate and end products of free-radical lipid peroxidation (FR LPO)--diene conjugates (DC) and malonic dialdehyde (MDA)--were studied in children subjected to different types of anesthesia. Ketamine in combination with clofelin helped reduce the activity of FR LPO. This was confirmed by the minimal changes in the activities of SOD, C, and RCPR, and the lowest level of accumulation of DC and MDA in children operated on under ketamine-clofelin narcosis.