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Updated: Aug 15, 2026

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
Published on: July 17, 2012
Stunned myocardium, an opinionated review
1W. G. Kerckhoff-Institut, Max-Planck-Institut für physiologische und klinische Forschung Abt. Experimentelle Kardiologie, Bad Nauheim.
Abstract:
Brief coronary occlusions cause stunning and ischemic preconditioning, the molecular mechanisms of which are insufficiently known. A marked reprogramming of sarcolemmal functions (including those of the sarcoplasmic reticulum) seems to occur and may be the basis for many of the observed phenomena. A bewilderingly complex pattern of gene expression emerges from mRNA-studies with reperfused tissue which at present does not permit a focussed or coherent view of mechanisms.
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