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Updated: Aug 16, 2026

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
Published on: March 9, 2013
Hematocrit has no effect on peritoneal transport indices
C Gandolfo1, G Battista, G Viglino
1Nephrology and Dialysis Service, Regional Hospital, Alba, Italy.
Abstract:
To assess the effect of hematocrit (Hct) on peritoneal transport indices (PTi), we studied the relationship between Hct (mean 28.1 +/- 5.1%, range 19.1-41.3%) and PTi with 118 peritoneal equilibration tests (PETs; 270 min, 1.36%) on 52 stable patients on peritoneal dialysis. Furthermore, considering a Hct 30% as ideal in peritoneal dialysis (PD), 14 patients who had performed a PET both with a Hct <30% and > or = 30% were checked for any variations in the PTi and blood pressure. We analyzed the subsequent PTi: ultrafiltration; creatinine (Cr) and blood urea nitrogen (BUN) clearance and mass transfer area coefficient (MTAC); 120, 240, and 270 min Cr D/P, UN D/P and glucose D/D0. Linear regressions between Hct and the PTi (118 PETs) did not prove statistically significant. The analysis of the PTi in 14 patients who had performed a PET with both a Hct < 30% and > or = 30% did not prove statistically significant, and no change in blood pressure was demonstrated. We do not consider Hct to have a significant influence on PTi.
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