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Updated: Sep 3, 2026

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Pigmented hyperplasia of epidermis following feeding of L-dopa to elderly rats
Journal of the National Cancer Institute
|May 1, 1977
Abstract:
In view of clinical data supporting a casual relationship between long-term L-dopa administration and recurrence of melanoma, long-term L-dopa administration to aged rats was performed to investigate its effect on the incidence of malignant melanoma. Of the treated animals, 11% showed local pigmented epidermal hyperplasia, compared with 0.5% of the control animals, but the number of expected melanomas was not increased by L-dopa treatment.

