Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitric oxide and liver disease

G A Abrams1, M Trauner, M H Nathanson

  • 1Liver Study Unit, Yale University School of Medicine, New Haven, CT 06520, USA.

The Gastroenterologist
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary sclerosing cholangitis: Time to rethink imaging criteria for early disease detection.

Journal of hepatology·2026
Same author

Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Anaemia is independently associated with mortality in patients with hepatocellular carcinoma.

ESMO open·2024
Same author

Clinical characteristics and outcome of patients with combined hepatocellular-cholangiocarcinoma-a European multicenter cohort.

ESMO open·2023
Same author

What can anaesthetists do to help combat the global climate emergency?

Anaesthesia·2022
Same author

Cancer and hepatic steatosis.

ESMO open·2021

Nitric oxide impacts liver health, causing acute dysfunction during infections and chronic issues like cirrhosis. Understanding its role is key for treating liver diseases.

Area of Science:

  • Hepatology
  • Physiology
  • Pathophysiology

Background:

  • Nitric oxide (NO) is a reactive gas with diverse physiological and pathophysiological effects.
  • The liver is significantly influenced by NO, with acute and chronic exposure leading to distinct liver diseases.
  • Bacterial infections and sepsis acutely increase NO, potentially causing hepatic dysfunction and cholestasis.

Purpose of the Study:

  • To review the role of nitric oxide in acute and chronic liver diseases.
  • To explore the etiology, diagnosis, and treatment of cholestasis associated with infections.
  • To examine the connection between NO and hepatorenal and hepatopulmonary syndromes in end-stage liver disease.

Main Methods:

  • Literature review of studies on nitric oxide in liver disease.

Related Experiment Videos

  • Analysis of the impact of acute NO increase during infections on liver function.
  • Review of chronic NO effects on conditions like cirrhosis and portal hypertension.

    • Main Results:

    • Acute NO increase is linked to hepatic dysfunction and cholestasis in infections.
    • Chronic NO elevation may contribute to hyperdynamic circulation in cirrhosis and portal hypertension.
    • Nitric oxide is implicated in hepatorenal and hepatopulmonary syndromes.

    Conclusions:

    • Nitric oxide plays a critical role in various liver conditions, from acute infectious complications to chronic diseases.
    • Understanding NO's role is essential for developing effective treatment strategies for liver diseases.
    • Further research into NO's mechanisms in hepatology is warranted.