Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patients requiring sedation

A Tung1, M Rosenthal

  • 1Department of Anesthesia, Stanford University School of Medicine, California, USA.

Critical Care Clinics
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Sedative drugs are increasingly used in intensive care units (ICUs), but their indications and assessment remain unclear. While new uses are proposed, evidence for their effectiveness is still developing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM).

Journal of neuro-oncology·2024
Same author

Correction to: A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma.

Journal of neuro-oncology·2024
Same author

A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma.

Journal of neuro-oncology·2023
Same author

In search of the perfect outcome in neuroanaesthesia and neurocritical care.

Anaesthesia·2022
Same author

Clinical outcomes in men of diverse ethnic backgrounds with metastatic castration-resistant prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Microstructural metrology of tobacco mosaic virus nanorods during radial compression and heating.

Soft matter·2017
Same journal

Critical Care and Contagion: Evolving Frontiers of Infectious Diseases in the Modern Intensive Care Unit.

Critical care clinics·2026
Same journal

Advances and Challenges in Sepsis Care in Low-Resource Settings.

Critical care clinics·2026
Same journal

The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus.

Critical care clinics·2026
Same journal

Antibiotic Stewardship for the Intensivist.

Critical care clinics·2026
Same journal

Infection Prevention and Control in the Intensive Care Unit.

Critical care clinics·2026
Same journal

Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing.

Critical care clinics·2026
See all related articles

Area of Science:

  • Pharmacology
  • Intensive Care Medicine

Background:

  • Sedative drug use in ICUs has increased due to recent pharmacological advances.
  • Current indications and endpoints for sedation are often poorly defined and challenging to assess.
  • Complications associated with sedative drug administration are a significant concern.

Purpose of the Study:

  • To review the expanded use of sedative drugs in ICUs.
  • To highlight the challenges in defining and assessing sedation indications and endpoints.
  • To discuss emerging indications for sedation and the current evidence base.

Main Methods:

  • Literature review of recent advances in sedative pharmacology.
  • Analysis of current practices and challenges in ICU sedation.
  • Evaluation of evidence for novel sedation indications.

Related Experiment Videos

Main Results:

  • Sedative pharmacology has advanced, broadening ICU applications.
  • Assessment of sedation efficacy and complications remains difficult.
  • New indications like sleep/wake cycle enforcement and myocardial ischemia prevention are under investigation.

Conclusions:

  • Despite expanded use, clear guidelines for ICU sedation are lacking.
  • Further research is needed to validate the efficacy and safety of novel sedation indications.
  • Careful consideration of potential complications is essential when administering sedatives.