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Exercise and haemostatic function

T W Meade1

  • 1MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College, St Bartholomew's Hospital, London, UK.

Journal of Cardiovascular Risk
|August 1, 1995
PubMed
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Regular vigorous exercise lowers plasma fibrinogen, reducing ischaemic heart disease risk. However, sudden strenuous activity increases immediate risk, so gradually increase exercise intensity.

Area of Science:

  • Cardiovascular Health
  • Exercise Physiology
  • Hematology

Background:

  • Ischaemic heart disease (IHD) risk is reduced by sustained vigorous exercise.
  • Exercise benefits may stem from short-term effects on the haemostatic system and thrombogenic potential.
  • High plasma fibrinogen is a significant independent risk factor for IHD.

Purpose of the Study:

  • To investigate the effects of exercise on plasma fibrinogen levels.
  • To quantify the impact of exercise-induced fibrinogen reduction on IHD risk.
  • To examine the short-term effects of exertion on cardiovascular risk.

Main Methods:

  • Review of one randomized controlled trial.
  • Analysis of several large epidemiological studies.
  • Assessment of exercise's influence on plasma fibrinogen and coagulability.

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Main Results:

  • Vigorous exercise significantly lowers plasma fibrinogen levels.
  • Reduced fibrinogen from exercise can decrease IHD risk by an estimated 7-8%.
  • Unaccustomed exertion may transiently increase coagulability and immediate IHD risk.

Conclusions:

  • Consistent vigorous exercise offers protective benefits against IHD, partly via fibrinogen reduction.
  • Individuals unaccustomed to exercise should initiate programs gradually to mitigate short-term risks.
  • Exercise interventions targeting fibrinogen present a viable strategy for IHD prevention.