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[The desogestrel-ethinyl estradiol combination and overweight: current data]

B Rubio Lotvin1

  • 1Facultad de Medicina, Universidad Nacional Autónoma de México.

Ginecologia Y Obstetricia De Mexico
|November 1, 1995
PubMed
Summary

This study reviewed progestin-estrogen contraceptives and found desogestrel-ethynil estradiol effectively reduced body weight in obese patients to ideal levels without compromising contraceptive function.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Reproductive Health

Background:

  • Combined oral contraceptives containing progestins and ethinyl estradiol are widely used.
  • Previous research has explored their impact on body weight.
  • Obesity remains a significant public health concern requiring effective management strategies.

Purpose of the Study:

  • To evaluate the effect of desogestrel-ethinyl estradiol on body weight in obese patients.
  • To assess the safety and efficacy of this contraceptive in weight management.
  • To compare findings with previous studies on similar formulations.

Main Methods:

  • A cohort of obese patients was treated with desogestrel-ethinyl estradiol (150 mcg/30 mcg) for weight excess.
  • Patient outcomes were monitored under conditions similar to a 1992 study.

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  • Body weight changes were recorded until patients reached their ideal weight.

    • Main Results:

    • Patients treated with desogestrel-ethinyl estradiol experienced significant body weight loss.
    • Weight reduction continued until patients achieved their ideal body weight.
    • The contraceptive's efficacy was not negatively impacted by its effect on body weight.

    Conclusions:

    • Desogestrel-ethinyl estradiol demonstrates a favorable effect on body weight reduction in obese individuals.
    • This contraceptive formulation can be a viable option for obese women seeking weight management.
    • Further research may explore the mechanisms behind this weight-reducing effect.