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Platelet association with gingival tissue inflammation

A D Steinberg1, M E Alves, J Lipowski

  • 1Department of Periodontics and Biochemistry, University of Illinois at Chicago, USA.

Journal of Periodontology
|October 1, 1995
PubMed
Summary
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Platelet activation, indicated by beta-thromboglobulin release, was detected in gingival crevicular fluid. Higher levels of platelet activation correlated with increased gingival inflammation.

Area of Science:

  • Periodontology
  • Hematology
  • Inflammation Research

Background:

  • Platelets (PL) release factors contributing to gingival tissue injury.
  • Localized platelet constituent discharge can amplify inflammation.

Purpose of the Study:

  • To detect platelet activation in gingival crevicular fluid.
  • To correlate platelet activation with gingival inflammation severity (Gingival Index - GI).

Main Methods:

  • Assayed for beta-thromboglobulin (beta-TG), a platelet-specific activation marker.
  • Collected gingival crevicular fluid samples from human subjects with varying GI scores.
  • Quantified beta-TG levels using radioimmunoassay (RIA).

Main Results:

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  • Detectable beta-TG levels were found in all fluid samples (mean 5.5-45.2 ng/ml).
  • A positive association was observed between low GI scores (0-1) and beta-TG levels.
  • Beta-TG concentrations plateaued at higher GI scores (≥2).

    • Conclusions:

    • Findings provide evidence of platelet activation in the gingival crevice.
    • Suggests a relationship between platelet activation and the degree of gingival inflammation.