Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Familial pituitary tumors]

K Yoshimoto1, S Saito

  • 1Otsuka Department of Clinical and Molecular Nutrition, University of Tokushima.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 1, 1995
PubMed
Summary

Familial pituitary adenomas, distinct from Multiple Endocrine Neoplasia type 1, are rare. A high incidence of acromegaly and gigantism is noted in these rare familial pituitary tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards building a trustworthy pipeline integrating Neuroscience Gateway and Open Science Chain.

Database : the journal of biological databases and curation·2024
Same author

Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance.

Neuropathology and applied neurobiology·2019
Same author

Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma.

Diagnostic and interventional imaging·2019
Same author

MR Imaging-Based Analysis of Glioblastoma Multiforme: Estimation of IDH1 Mutation Status.

AJNR. American journal of neuroradiology·2015
Same author

Germline deletion and a somatic mutation of the PRKAR1A gene in a Carney complex-related pituitary adenoma.

European journal of endocrinology·2014
Same author

T-cell receptor ζ mRNA with an alternatively spliced 3' untranslated region is generated predominantly in the peripheral blood T cells of systemic lupus erythematosus patients.

Modern rheumatology·2014

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Familial pituitary tumors are rare, often associated with Multiple Endocrine Neoplasia type 1 (MEN 1).
  • Familial pituitary adenomas unrelated to MEN 1 are exceptionally rare, with only 45 cases reported globally.
  • Pituitary tumors are observed in 60% of MEN 1 patients in Japan.

Observation:

  • Acromegaly or gigantism constitutes 67% of reported familial pituitary adenomas.
  • This incidence is significantly higher than the 28% observed in MEN 1 patients with pituitary tumors.
  • Allelic deletions at 11q13 were found in both MEN 1-associated and familial pituitary adenomas in gigantism cases.

Findings:

  • Familial pituitary adenomas show a disproportionately high rate of acromegaly and gigantism compared to MEN 1-associated pituitary tumors.
  • Genetic analysis revealed shared chromosomal abnormalities (11q13 deletions) in distinct familial pituitary tumor types.

Implications:

  • Understanding the genetic basis of familial pituitary adenomas can aid in early diagnosis and targeted therapies.
  • Distinguishing familial pituitary adenomas from MEN 1 is crucial for accurate prognosis and management.
  • Further research into the specific genetic drivers of acromegaly/gigantism in familial pituitary adenomas is warranted.

Related Experiment Videos