Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary complications after bone marrow transplantation

H T Winer-Muram1, J W Gurney, P M Bozeman

  • 1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Radiologic Clinics of North America
|January 1, 1996
PubMed
Summary

Interpreting post-transplant lung complications on chest radiographs relies on the timing of abnormalities. Early signs may indicate fungal infections, while later diffuse changes suggest various issues, often requiring biopsy for diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noroviruses as a Cause of Diarrhea in Immunocompromised Pediatric Hematopoietic Stem Cell and Solid Organ Transplant Recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Robust T cell responses to aspergillosis in chronic granulomatous disease: implications for immunotherapy.

Clinical and experimental immunology·2013
Same author

Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution.

Leukemia & lymphoma·2010
Same author

Can FDG-PET be used to predict growth of stage I lung cancer?

Clinical radiology·2008
Same author

Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation (RISCT) using antilymphocyte antibodies in patients with high-risk acute myeloid leukemia (AML).

Bone marrow transplantation·2006
Same author

Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath).

Bone marrow transplantation·2005

Area of Science:

  • Radiology
  • Pulmonary Medicine
  • Transplant Medicine

Background:

  • Pulmonary complications post-transplantation often present with nonspecific radiographic findings.
  • Accurate interpretation of chest radiographs is critical for timely and effective patient management.

Purpose of the Study:

  • To elucidate the diagnostic significance of radiographic patterns in pulmonary complications following transplantation.
  • To correlate radiographic findings with specific etiologies and treatment strategies.

Main Methods:

  • Analysis of chest radiograph chronologic onset of abnormalities post-transplantation.
  • Differentiation of radiographic patterns based on timing (pre-engraftment vs. post-engraftment).
  • Consideration of differential diagnoses including infections, edema, hemorrhage, ARDS, and malignancy.

Related Experiment Videos

Main Results:

  • Early peripheral opacities with edema suggest fungal infections, treated with granulocyte transfusions and amphotericin B.
  • Diffuse interstitial thickening post-engraftment can indicate edema, hemorrhage, bacterial infection, ARDS, or viral infections like CMV.
  • Nodular opacities post-engraftment may represent opportunistic infections, BOOP, PTLPD, or recurrent tumors.

Conclusions:

  • The chronologic appearance of radiographic abnormalities is key to diagnosing pulmonary complications after transplantation.
  • Cytomegalovirus (CMV) pneumonitis is a common, treatable infection in allogeneic transplant recipients.
  • Open lung biopsy is often necessary for definitive diagnosis of complex or persistent pulmonary abnormalities.