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Updated: Aug 14, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
[Physiology and pathophysiology of sleep]
1Max-Planck-Institut für Psychiatrie, Klinisches Institut, Psychiatrische Klinik, München.
Abstract:
Human sleep is characterized by the cyclic occurrence of nonREM and REM periods and by distinct patterns of nocturnal hormone secretion. A host of factors may result in disturbed sleep, including normal aging and depression. In both states, similar changes in sleep-endocrine activity occur, including decreases in slow wave sleep and in growth hormone secretion. Preclinical investigations and studies by our laboratory in young and elderly normal controls and in patients with depression demonstrate that neuropeptides play a key role in sleep regulation. As an example, growth hormone-releasing hormone (GHRH) is a common stimulus of slow wave sleep and growth hormone release, whereas corticotropin-releasing hormone (CRH) exerts opposite effects. We suggest that an imbalance of both peptides in favor of CRH contributes to changes in sleep-endocrine activity during depression and aging.
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