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Regulation of adenosine receptors in cultured heart cells
D el-Ani1, K A Jacobson, A Shainberg
1Otto Meyerhoff Drug Receptor Center, Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Advances in Experimental Medicine and Biology
|January 1, 1995
Abstract:
A1 adenosine receptors were studied on heart cells grown in cultures by the radioligand binding technique. Treatments with agents that accelerated heart rate for 3-4 days, caused an increase in the level of adenosine receptors. Treatments that attenuated heart rate, reduced the level of the receptors. Thus, the cardiac cells respond to environmental conditions affecting heart contraction so as to restore the basal rate of heart activity.