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Seasons and bipolar disorder

D A D'Mello1, J A McNeil, B Msibi

  • 1Department of Psychiatry, Michigan State University, East Lansing 48823, USA.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|March 1, 1995
PubMed
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Bipolar disorder hospitalizations show seasonal patterns, peaking in spring for men and spring/fall for women. Aggressive behavior also peaks in spring, suggesting seasonality influences mood disorders.

Area of Science:

  • Psychiatry
  • Chronobiology
  • Mood Disorders

Background:

  • Bipolar disorder is a complex mood disorder with potential links to environmental factors.
  • Previous research suggests seasonal variations may influence the course of bipolar disorder.

Purpose of the Study:

  • To investigate seasonal variations in bipolar disorder patient hospitalizations.
  • To analyze the relationship between seasons and specific clinical parameters including aggressive behavior and lithium treatment.

Main Methods:

  • Retrospective analysis of 377 inpatient bipolar disorder patient records over a 6-year period.
  • Examination of seasonal trends in admission rates, sleep, thyroid stimulating hormone, creatinine, lithium levels, and aggressive behavior.

Main Results:

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  • Hospital admission rates for men peaked in spring; women showed bimodal peaks in spring and fall.
  • Aggressive behavior significantly increased in spring for both sexes (p < 0.05).
  • Men on lithium therapy exhibited higher serum lithium levels during summer months.

Conclusions:

  • Seasonal variations significantly impact bipolar disorder, affecting admission rates and aggressive behavior.
  • Findings support the influence of seasons on mood disorder presentation and lithium pharmacokinetics.
  • Therapeutic strategies may need to consider seasonal patterns for optimal bipolar disorder management.