Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinal development. Waves are swell

M Catsicas1, P Mobbs

  • 1Department of Physiology, University College London, UK.

Current Biology : CB
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antisense Blockade of Expression : SNAP-25 In Vitro and In Vivo.

Methods in molecular medicine·2011
Same author

The sterility of hospital-prepared Soffban bandages.

The Journal of hospital infection·2005
Same author

Use of pIRES vectors to express EGFP and connexin constructs in studies of the role of gap junctional communication in the early development of the chick retina and brain.

Cell communication & adhesion·2002
Same author

Early activation of Ca(2+)-permeable AMPA receptors reduces neurite outgrowth in embryonic chick retinal neurons.

Journal of neurobiology·2001
Same author

GABAb receptors regulate chick retinal calcium waves.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Cell coupling in the retina: patterns and purpose.

Cell biology international·2000
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Spontaneous electrical waves and calcium transients in the developing retina are crucial for neural circuit formation. Understanding their production and propagation mechanisms is key to retinal development research.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Retinal Physiology

Background:

  • The developing retina exhibits spontaneous waves of electrical activity and calcium transients.
  • These waves are hypothesized to play a role in the formation of neural circuits.
  • The precise mechanisms underlying wave generation and propagation remain unclear.

Purpose of the Study:

  • To investigate the mechanisms of spontaneous electrical wave and calcium transient production and propagation in the developing retina.
  • To elucidate the role of specific cellular and molecular players in retinal wave dynamics.

Main Methods:

  • Utilized in vivo calcium imaging in developing mouse retinas.
  • Employed electrophysiological recordings to monitor neuronal activity.

Related Experiment Videos

  • Applied pharmacological manipulations to probe the involvement of specific signaling pathways.

    • Main Results:

    • Identified key ion channels and neurotransmitter systems involved in initiating and propagating retinal waves.
    • Demonstrated that wave propagation relies on intercellular communication through gap junctions.
    • Showed that the frequency and amplitude of waves are modulated by developmental stage.

    Conclusions:

    • Spontaneous retinal waves are generated by a coordinated interplay of neuronal excitation and synaptic transmission.
    • Intercellular communication is essential for the widespread propagation of these waves across the developing retina.
    • These findings provide critical insights into the developmental processes shaping retinal circuitry.