Herpes simplex virus-1 latency and its implications for gene therapy of the nervous system

Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters.

Gene therapy·2009

Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.

Nature·2006

The cellular response to herpes simplex virus type 1 (HSV-1) during latency and reactivation.

Journal of neurovirology·2005

Stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector.

Molecular therapy : the journal of the American Society of Gene Therapy·2005

During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.

Journal of virology·2004

Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.

Journal of virology·2001

Culture media alter retinal organoid physiology promoting AAV transduction and retinal ganglion cell survival.

Gene therapy·2026

Optogenetic vision restoration: translational barriers and emerging therapeutic strategies.

Gene therapy·2026

Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study.

Gene therapy·2026

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production.

Gene therapy·2026

A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease.

Gene therapy·2026

Precision correction of the GJB2 c.235delC mutation by prime editing in vitro.

Gene therapy·2026

Prognostic value of cardiac magnetic resonance global T2 mapping in patients with Takotsubo syndrome.

European heart journal. Cardiovascular Imaging·2026

Efficacy and Safety of Baxdrostat in Hypertension: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The Annals of pharmacotherapy·2026

Route- and sex-dependent toxicity of clinical-stage silver nanoparticles in mice.

Nanoscale·2026

Glucosamine functionalized multi-walled carbon nanotubes as potential antibacterial molecules.

International microbiology : the official journal of the Spanish Society for Microbiology·2026

Impact of the HPV vaccination programme on anal HPV infection in gay, bisexual and other men who have sex with men: multi-site enhanced surveillance study in specialist sexual health services in England.

Vaccine·2026

Incidence, Risk Factors, and Economic Impact of Bleeding After Renal Biopsy: A Prospective Cohort Study.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2026

Related Experiment Videos

Herpes simplex virus-1 latency and its implications for gene therapy of the nervous system

Related Concept Videos

Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters.

Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.

The cellular response to herpes simplex virus type 1 (HSV-1) during latency and reactivation.

Stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector.

During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.

Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.

Culture media alter retinal organoid physiology promoting AAV transduction and retinal ganglion cell survival.

Optogenetic vision restoration: translational barriers and emerging therapeutic strategies.

Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study.

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production.

A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease.

Precision correction of the GJB2 c.235delC mutation by prime editing in vitro.

Prognostic value of cardiac magnetic resonance global T2 mapping in patients with Takotsubo syndrome.

Efficacy and Safety of Baxdrostat in Hypertension: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Route- and sex-dependent toxicity of clinical-stage silver nanoparticles in mice.

Glucosamine functionalized multi-walled carbon nanotubes as potential antibacterial molecules.

Impact of the HPV vaccination programme on anal HPV infection in gay, bisexual and other men who have sex with men: multi-site enhanced surveillance study in specialist sexual health services in England.

Incidence, Risk Factors, and Economic Impact of Bleeding After Renal Biopsy: A Prospective Cohort Study.

Related Experiment Videos

Herpes simplex virus-1 latency and its implications for gene therapy of the nervous system

Related Concept Videos

Related Articles