Related Experiment Videos
Exacerbation of nickel induced oxidative response by vitamin E
1Industrial Toxicology Research Centre, Mahatma Gandhi Marg Lucknow, India.
Industrial Health
|January 1, 1995
Abstract:
Vitamin E (alpha-tocopherol), a well known naturally occurring chain breaking antioxidant and a free radical scavenger was found to exacerbate nickel (Ni) toxicity in mice. Vitamin E (Vit. E) mediated enhancement of nickel toxicity was demonstrated by (i) enhanced mortality in mice treated with Ni and Vit. E (ii) increased hepatic lipid peroxidation, (iii) increased rate of benzoate hydroxylation, and (iv) liposomal membrane damage.