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Enterovirus specific IgM responses in children with acute and chronic paralytic syndrome
U Tuteja1, G Pandya, R Bharagava
1Department of Microbiology, Defence Research and Development Establishment, Gwalior, India.
Insights
Enterovirus IgM antibodies were detected in children with paralysis. Poliovirus, Coxsackievirus B3, and Coxsackievirus A7 IgM were associated with acute paralysis, while Coxsackievirus A7 IgM predominated in chronic paralysis cases.
Area of Science:
- Virology
- Immunology
- Pediatrics
Background:
- Enteroviruses are a common cause of paralytic illness in children.
- Early diagnosis and identification of enterovirus types are crucial for understanding disease pathogenesis and management.
Purpose of the Study:
- To investigate the role of enterovirus-specific IgM responses in children with acute and chronic paralytic syndromes.
- To identify specific enterovirus types associated with different clinical presentations of paralysis.
Main Methods:
- Detection of enterovirus-specific IgM antibodies using IgM antibody capture enzyme immunoassay.
- Analysis of sera from 51 children with acute paralysis and 8 children with chronic paralysis.
Main Results:
- 56.86% of acute phase sera showed enterovirus IgM (Poliovirus, CVB3, CVA7).
- Poliovirus IgM was often associated with CVB3 and CVA7 in acute cases.
- Coxsackievirus A7 specific IgM was predominant in 6 out of 8 chronically paralytic children.
Conclusions:
- Enterovirus IgM responses are indicative of infection in children with paralytic syndromes.
- Distinct enterovirus serotypes may be associated with acute versus chronic paralysis.
- Further research is needed to elucidate the specific roles of different enteroviruses in paralytic disease.
Abstract:
Enterovirus specific IgM responses in 51 children aged 0-7 years with acute, clinically diagnosed paralytic syndrome and 8 children with chronic paralysis were detected by IgM antibody capture enzyme immunoassay. Twenty-nine out of 51 (56.86%) acute phase sera were positive for enterovirus (Polio, CVB3 and CVA7) IgM antibodies, in 21 of whom poliovirus antibodies were found in close association with CVB3 and CVA7. On the other hand, preponderance of CVA7 specific IgM was detected in 6 out of 8 sera samples of chronically paralytic children.