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Squamous cell carcinoma arising in inverted papilloma
M M Lesperance1, R M Esclamado
1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, USA.
The Laryngoscope
|February 1, 1995
Summary
Inverted papilloma (IP) can develop into squamous cell carcinoma (SCC), with 27% of cases showing this association. Long-term follow-up is crucial for early detection and improved outcomes.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Inverted papilloma (IP) is a benign nasal tumor.
- A significant percentage of IPs are associated with squamous cell carcinoma (SCC).
Purpose of the Study:
- To evaluate the incidence of squamous cell carcinoma (SCC) in inverted papilloma (IP) cases.
- To determine the prognostic factors for disease-free survival in patients with IP and SCC.
- To recommend optimal management and follow-up strategies.
Main Methods:
- Retrospective review of 51 inverted papilloma cases diagnosed between 1975 and 1992.
- Analysis of associated squamous cell carcinoma (synchronous and metachronous).
- Evaluation of disease-free survival based on tumor extent and treatment approach.
Main Results:
- 14% of inverted papilloma cases (27%) had an associated squamous cell carcinoma.
- Disease-free survival was significantly lower for tumors extending beyond the nasal cavity and paranasal sinuses (14%) compared to those limited to these areas (57%).
- The mean interval between IP diagnosis and SCC development was 63 months.
Conclusions:
- Inverted papilloma carries a risk of malignant transformation to squamous cell carcinoma.
- Early detection through long-term clinical and imaging follow-up (CT scans) is essential.
- Surgical resection (lateral rhinotomy with medial maxillectomy and ethmoidectomy) followed by radiation therapy is recommended.