Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential molecular genetic changes in lung cancer development

G T Chung1, V Sundaresan, P Hasleton

  • 1MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.

Oncogene
|December 21, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparison of patient-reported outcomes in patients undergoing abdominal wall repair with either synthetic or biosynthetic mesh: a pilot study.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

High-Level Ciprofloxacin-Resistant Campylobacter jejuni Isolates Circulating in Humans and Animals in Incheon, Republic of Korea.

Zoonoses and public health·2016
Same author

Outbreak of enterotoxigenic Escherichia coli O169 enteritis in schoolchildren associated with consumption of kimchi, Republic of Korea, 2012.

Epidemiology and infection·2013
Same author

The influence of sex and histology on outcomes in non-small-cell lung cancer: a pooled analysis of five randomized trials.

Annals of oncology : official journal of the European Society for Medical Oncology·2010
Same author

Cryptogenic fibrosing alveolitis and lung cancer: the BTS study.

Thorax·2009
Same author

Microdissection molecular copy-number counting (microMCC)--unlocking cancer archives with digital PCR.

The Journal of pathology·2008
Same journal

Aberrant splicing in human cancer shows possible functional impact on transcription factors.

Oncogene·2026
Same journal

The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression.

Oncogene·2026
Same journal

Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway.

Oncogene·2026
Same journal

Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C-mutant non-small cell lung cancer.

Oncogene·2026
Same journal

Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.

Oncogene·2026
Same journal

Correction: SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle.

Oncogene·2026
See all related articles

Genetic changes in premalignant bronchial lesions show that chromosome 3 allele loss occurs before p53 gene damage in lung cancer development. This finding aids in localizing tumor suppressor genes.

Area of Science:

  • Oncology
  • Genetics
  • Pulmonology

Background:

  • Epithelial tumors arise from pre-invasive lesions driven by somatic genetic alterations.
  • Lung cancer development involves sequential genetic changes in bronchial epithelium.

Purpose of the Study:

  • To investigate the sequence of common genetic alterations in premalignant bronchial lesions.
  • To determine the order of allele loss on chromosome 3 and p53 gene damage in lung tumorigenesis.
  • To explore the utility of preneoplastic lesions for tumor suppressor gene mapping.

Main Methods:

  • Analysis of somatic genetic changes in a series of premalignant bronchial lesions.
  • Comparative study of allele loss patterns in dysplasia versus invasive tumors.
  • Deletion mapping using interstitial and homozygous deletions.

Related Experiment Videos

Main Results:

  • Evidence suggests allele loss on chromosome 3 precedes p53 gene damage.
  • Chromosome 3 damage appears sequential, with discrete allele loss in dysplasia.
  • Comparison of deletions refined the localization of a lung cancer-associated tumor suppressor gene.

Conclusions:

  • Premalignant bronchial lesions are valuable for studying genetic alterations in lung cancer.
  • The sequential nature of genetic damage aids in identifying tumor suppressor gene locations.
  • Understanding early genetic events is crucial for lung cancer development research.