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[Anti-thyroid autoantibodies in hepatitis C. Thyroid function after interferon therapy in 4 patients]
J F Broussard1, A Tran, S Benzaken
1Service d'Hépato-Gastroentérologie, Hôpital de l'Archet, Nice.
Presse Medicale (Paris, France : 1983)
|November 18, 1995
Summary
Hepatitis C patients with antithyroid antibodies may develop thyroid dysfunction after interferon therapy. This dysfunction can reverse after stopping treatment, indicating a potential link between interferon and thyroid health.
Area of Science:
- Hepatology
- Immunology
- Endocrinology
Context:
- Chronic hepatitis C infection.
- Presence of antithyroid autoantibodies.
- Euthyroid state prior to treatment.
Purpose:
- To investigate the effect of interferon therapy on thyroid function in hepatitis C patients with antithyroid autoantibodies.
Summary:
- Four female patients with chronic hepatitis C and antithyroid autoantibodies received recombinant interferon alpha therapy.
- Two patients developed hypothyroidism during treatment; one remained euthyroid.
- Thyroid function normalized in one patient post-treatment, while another maintained normal aminotransferase levels.
Impact:
- Interferon administration may induce transient thyroid dysfunction in susceptible patients.
- Thyroid dysfunction observed in this cohort was reversible upon cessation of cytokine therapy.
- Highlights the importance of monitoring thyroid function during interferon treatment for hepatitis C.