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In vitro stability of ranitidine hydrochloride in enteral nutrient formulas
R S Crowther1, R Bellanger, K E Szauter
1Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555, USA.
Objective:
To determine the chemical stability and physical compatibility of ranitidine in enteral nutrient formulas.
Measurements:
A stability-indicating HPLC assay was used to measure the recovery of ranitidine from tablet (dissolved in water) or syrup after up to 24 hours of in vitro incubation in a variety of enteral nutrient formulas. Ranitidine binding to components of the formulas was measured after ultrafiltration.
Results:
Eight enteral nutrient formulas were studied, and more than 90% of added ranitidine was recovered from each formula after 24 hours. The amount of ranitidine bound to components of the formulas varied between 8% and 29%. No gross physical incompatibilities were seen and the pH of each formula changed by less than 0.1 pH units over 24 hours.
Conclusions:
Ranitidine from either tablet or syrup was stable in the enteral nutrient formulas studied. Administration of ranitidine by admixture into these enteral formulas may be feasible.