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Eosinophilia associated with bupropion
M A Malesker1, G S Soori, P M Malone
1Immanuel Medical Center, Omaha, NE, USA.
The Annals of Pharmacotherapy
|September 1, 1995
Summary
This case study reports the first known instance of eosinophilia, a condition marked by elevated eosinophils, linked to bupropion medication. The patient
Area of Science:
- Pharmacology
- Hematology
- Clinical Medicine
Background:
- Bupropion is an antidepressant medication.
- Eosinophilia is an increase in eosinophils, a type of white blood cell.
- Medication-induced eosinophilia is a known phenomenon.
Observation:
- A 72-year-old woman developed significant eosinophilia (absolute count 6693 x 10(6)/L) after 5 days of bupropion therapy.
- Other potential causes for eosinophilia were systematically excluded.
- Eosinophil levels rapidly decreased after bupropion was discontinued.
Findings:
- This case represents the first documented incidence of eosinophilia associated with bupropion.
- The temporal relationship strongly suggests bupropion as the causative agent.
- The exact mechanism linking bupropion to eosinophilia remains undetermined.
Implications:
- Clinicians should consider bupropion as a potential cause of eosinophilia.
- This finding expands the known adverse drug reactions associated with bupropion.
- Further research may be warranted to elucidate the underlying pathophysiology.