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Quinolone activity against anaerobes: microbiological aspects
1Department of Pathology, Hershey Medical Center, Pennsylvania, USA.
Drugs
|January 1, 1995
Summary
Newer quinolones show promising activity against anaerobic bacteria, though some established drugs are ineffective. Further research is needed to determine their clinical use for anaerobic infections.
Area of Science:
- Microbiology
- Pharmacology
Background:
- Current quinolone antibiotics exhibit limited efficacy against anaerobic bacteria.
- Anaerobic bacterial infections pose significant therapeutic challenges.
Purpose of the Study:
- To review the in vitro activity of existing and investigational quinolones against clinically relevant anaerobic bacteria.
- To identify quinolone compounds with potent anti-anaerobic properties.
Main Methods:
- Literature review of in vitro studies assessing quinolone activity.
- Categorization of quinolones based on their Minimum Inhibitory Concentrations (MICs) against anaerobic species.
Main Results:
- Ciprofloxacin, ofloxacin, and levofloxacin demonstrated low activity against anaerobes.
- Sparfloxacin and grepafloxacin showed intermediate activity.
- Clinafloxacin, DU 6859a, and CP 99,219 exhibited high in vitro activity.
- Development of some potent agents was halted due to toxicity concerns.
Conclusions:
- Certain novel quinolones possess significant in vitro activity against anaerobic bacteria.
- Further clinical, toxicological, and pharmacokinetic studies are essential to establish the therapeutic value of these agents in treating anaerobic infections.