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Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide
M M Mahoney1, A Y Lee, D J Brezinski-Caliguri
1Department of Medicine, Boston Children's Hospital, MA 02115, USA.
FEBS Letters
|December 27, 1995
Abstract:
Cathelin-related genes are characterized by the presence of a prepro sequence which is highly conserved both within and between species. 3' RACE analysis on sheep bone marrow RNA, using a primer based on a conserved cathelin family coding region, demonstrated the presence of at least three ovine cathelin-related cDNAs. One of these encodes a novel prepropeptide with a predicted C-terminal cleavage product RGLRRLGRKIAHG-VKKYGPTVLRIIRIAG. The chemically synthesized form of this 29 amino acid peptide is shown to be a thermostable, broad spectrum, bactericidal agent.