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Related Concept Videos

Development of Antibiotic Resistance01:30

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
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When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
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Labile antibiotic resistance in Staphylococcus aureus

W C Noble1, S A Howell

  • 1Department of Microbial Diseases, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

The Journal of Hospital Infection
|October 1, 1995
PubMed
Summary

This study identified Staphylococcus aureus isolates with unusual pigmentation and low-level mupirocin resistance. Genetic analysis revealed variations, highlighting challenges in outbreak detection using single typing methods.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Staphylococcus aureus is a significant human pathogen.
  • Antimicrobial resistance, including to mupirocin, is a growing concern.
  • Accurate strain typing is crucial for tracking outbreaks.

Purpose of the Study:

  • To investigate the characteristics of Staphylococcus aureus isolates with unusual pigmentation.
  • To assess the genetic relatedness and antibiotic resistance profiles of these isolates.
  • To evaluate the effectiveness of different typing methods in outbreak detection.

Main Methods:

  • Isolation and culture of Staphylococcus aureus.
  • Phenotypic characterization (pigmentation, antibiotic susceptibility testing).
  • Molecular typing (phage typing, plasmid profiling, SmaI DNA digestion).

Main Results:

  • Twenty-two Staphylococcus aureus isolates showed salmon pink pigmentation and low-level mupirocin resistance.
  • Most isolates shared the same phage type, but plasmid profiles and antibiotic resistances varied.
  • DNA digestion revealed distinct patterns in some isolates, suggesting genetic heterogeneity.

Conclusions:

  • Unusual pigmentation in Staphylococcus aureus can indicate an outbreak.
  • Relying on a single typing method may miss small outbreaks or misrepresent strain relatedness.
  • Combined molecular typing approaches are essential for comprehensive epidemiological surveillance.