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Monamidocin, a novel fibrinogen receptor antagonist. I. Production isolation, characterization and structural
T Kamiyama1, T Umino, Y Itezono
1Nippon Roche Research Center, Kamakura, Japan.
The Journal of Antibiotics
|November 1, 1995
Abstract:
Monamidocin, a novel fibrinogen receptor antagonist, has been isolated from the culture broth of Streptomyces sp. NR 0637 BY carbon adsorption, n-BuOH extraction, SP-Toyopearl, silica gel 60 silanised and Sephadex LH-20 column chromatographies and preparative HPLC. The molecular formula of monamidocin has been determined to be C15H22N4O4 from HRFAB-MS and 13C NMR spectral data. The structure of monamidocin has been determined to be N-[(S)-5-guanidino-2-hydroxypentanoyl]-L-phenylalanine by 2D NMR experiments.