Related Experiment Video
Updated: Aug 11, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Management of scar contractures, hypertrophic scars, and keloids
D A Sherris1, W F Larrabee, C S Murakami
1Department of Otolaryngology-HNS, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
Aberrant fibrous tissue formation after surgery or trauma still presents a challenge to surgeons. Current research hopes to identify the characteristics of the population of fibroblasts that lead to hypertrophic or keloid scar formation. Surgical procedures and laser therapy followed by intralesional steroid treatments still are the foundation of treatment; but new modalities are being applied. The pathogenesis and management of hypertrophic scars, keloids, and scar contractures are discussed in this article.
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