Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Towards molecular oncology

R R Brentani1, M M Brentani

  • 1Department of Oncologic and Radiologic, University of São Paulo.

Revista Do Hospital Das Clinicas
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Genetic alterations in oncogenes and tumor suppressor genes impact cancer prognosis. Detecting mutations in tumor suppressor genes can predict risk for gastrointestinal adenocarcinomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Set of miRNAs, Their Gene and Protein Targets and Stromal Genes Distinguish Early from Late Onset ER Positive Breast Cancer.

PloS one·2016
Same author

The effects of urban particulate matter on the nasal epithelium by gender: An experimental study in mice.

Environmental pollution (Barking, Essex : 1987)·2016
Same author

Prognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast cancer.

Oncology reports·2011
Same author

Attenuation of glucocorticoid receptor levels by the H-ras oncogene.

Endocrine·2010
Same author

Gene trio signatures as molecular markers to predict response to doxorubicin cyclophosphamide neoadjuvant chemotherapy in breast cancer patients.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2010
Same author

Human breast tumor slices: a model for identification of vitamin D regulated genes in the tumor microenvironment.

The Journal of steroid biochemistry and molecular biology·2010
Same journal

Laparoscopic bariatric surgery: new technologies, trends and perspectives.

Revista do Hospital das Clinicas·2006
Same journal

Human identification and analysis of DNA in bones.

Revista do Hospital das Clinicas·2005
Same journal

Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility.

Revista do Hospital das Clinicas·2005
Same journal

Use of nonradioactive labeling to detect large gene rearrangements in 21-hydroxylase deficiency.

Revista do Hospital das Clinicas·2005
Same journal

Prognostic factors in locally advanced colon cancer treated by extended resection.

Revista do Hospital das Clinicas·2005
Same journal

Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males.

Revista do Hospital das Clinicas·2005
See all related articles

Area of Science:

  • Oncology
  • Cancer Genetics

Background:

  • Genetic alterations like oncogene amplification and loss of heterozygosity (LOH) are observed in various human tumors.
  • These genetic changes are linked to patient prognosis across different cancer types.

Purpose of the Study:

  • To investigate the role of genetic alterations in tumor suppressor genes.
  • To determine if mutations in tumor suppressor genes can serve as risk factors in gastrointestinal adenocarcinomas.

Main Methods:

  • Analysis of genetic alterations including gene amplification and LOH.
  • Mutation detection in tumor suppressor genes.

Main Results:

  • Correlation established between oncogene amplification and LOH with prognosis in diverse human tumors.

Related Experiment Videos

  • Identification of tumor suppressor gene mutations as significant risk factor determinants.

    • Conclusions:

    • Genetic alterations in oncogenes and tumor suppressor genes are critical prognostic indicators.
    • Mutation status of tumor suppressor genes is a valuable determinant for risk stratification in gastrointestinal adenocarcinomas.