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[Reference values for trace elements in biological fluids]

P Apostoli1

  • 1Istituto di Medicina del Lavoro, Università degli Studi, Brescia.

Annali Dell'Istituto Superiore Di Sanita
|January 1, 1995
PubMed
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Establishing reliable reference ranges for element concentrations in biological fluids is crucial for assessing occupational and environmental exposure risks. Strict criteria in sample collection, analysis, and statistical treatment are essential for accurate range production.

Area of Science:

  • Environmental Science
  • Toxicology
  • Biochemistry

Context:

  • Accurate reference ranges for elemental concentrations in biological fluids are vital for risk assessment.
  • Occupational and environmental exposures necessitate reliable biological monitoring data.
  • Establishing these ranges requires rigorous methodological adherence.

Purpose:

  • To outline the essential criteria for developing reliable reference ranges for elemental concentrations in biological fluids.
  • To discuss factors influencing analytical and biological variability in elemental concentration measurements.
  • To inform the accurate assessment of health risks from environmental and occupational exposures.

Summary:

  • Reliable reference ranges for biological fluid element concentrations are necessary for risk assessment.

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  • Production of these ranges demands strict criteria for individual selection, sample collection, analytical control, and statistical analysis.
  • Factors like absorption route, pollution, physiology, and lifestyle impact variability and must be considered.

    • Impact:

    • Enhances the accuracy of occupational and environmental exposure risk evaluations.
    • Provides a framework for improving the reliability of biological monitoring studies.
    • Contributes to better public health protection by refining exposure assessment methodologies.