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Structure-function relationships of phenylalanine hydroxylase revealed by radiation target analysis

M D Davis1, M A Parniak, S Kaufman

  • 1National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.

Archives of Biochemistry and Biophysics
|January 15, 1996
PubMed
Summary

Radiation target analysis reveals phenylalanine hydroxylase (PAH) tetramers contain two active dimers. Tetrahydrobiopterin (BH4) binding to PAH tetramers inhibits enzymatic activity, affecting phenylalanine metabolism.

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