Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pierce-Donachy pediatric VAD: progress in development

B B Daily1, T W Pettitt, S P Sutera

  • 1Division of Cardiothoracic Surgery, Washington University, St. Louis, Missouri, USA.

The Annals of Thoracic Surgery
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilization of enzyme markers to determine the location of plasma membrane from Pisum epicotyls on sucrose gradients.

Planta·2013
Same author

The Disposal of Garbage.

Journal. Massachusetts Association of Boards of Health·2009
Same author

The beneficial hemodynamic effects of selective patent vertical vein following repair of obstructed total anomalous pulmonary venous drainage in infants.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2001
Same author

Repair of coarctation in a right-sided circumflex retroesophageal aortic arch.

The Annals of thoracic surgery·2001
Same author

Modifications in surgical implantation of the Penn State electric total artificial heart.

The Annals of thoracic surgery·2001
Same author

The LionHeart LVD-2000: a completely implanted left ventricular assist device for chronic circulatory support.

The Annals of thoracic surgery·2001

Developing pediatric ventricular assist devices is crucial for neonates. New bileaflet valves show promise in improving flow dynamics and reducing thrombus formation in these critical devices.

Area of Science:

  • Biomedical Engineering
  • Pediatric Cardiology
  • Medical Device Development

Background:

  • Pediatric ventricular assist devices (VADs) are lacking, despite adult VAD success.
  • Neonates (3-5 kg) requiring VADs for cardiogenic shock or transplant bridge face challenges with scaled-down adult devices.
  • Small valves and thrombus formation hinder pediatric VAD development.

Purpose of the Study:

  • Report progress on the Pierce-Donachy pediatric ventricular assist device.
  • Incorporate 10-mm bileaflet valve prototypes for pediatric VADs.
  • Quantify internal pump velocity fields using particle image velocimetry.

Main Methods:

  • Development of the Pierce-Donachy pediatric ventricular assist device.
  • Utilizing 10-mm-diameter bileaflet valve prototypes.

Related Experiment Videos

  • Employing particle image velocimetry (PIV) for flow analysis.

    • Main Results:

    • PIV velocity maps reveal complex flow patterns within the pediatric VAD.
    • Flow complexity suggests potential for hemodynamic improvement with optimized valves.
    • Ongoing animal tests will assess thrombus reduction via improved flow and surface "washing".

    Conclusions:

    • Optimizing valve hemodynamics may improve flow patterns in pediatric VADs.
    • Further research is needed to confirm reduced thrombus formation.
    • Successful pediatric VAD development requires addressing flow dynamics and hemocompatibility.