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Warfarin-induced eosinophilic pleurisy

T Kuwahara1, M Hamada, Y Inoue

  • 1Second Department of Internal Medicine, Ehime University School of Medicine.

Internal Medicine (Tokyo, Japan)
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Warfarin, a common anticoagulant, can cause eosinophilic pleurisy, a rare lung condition. This case report highlights the potential adverse effect of warfarin in patients experiencing unexplained pleural effusion and blood eosinophilia.

Area of Science:

  • Cardiology
  • Pulmonology
  • Pharmacology

Background:

  • Coronary artery bypass grafting (CABG) often necessitates anticoagulant therapy.
  • Warfarin is a widely used anticoagulant medication.
  • Pleural effusion and eosinophilia are potential indicators of adverse drug reactions.

Observation:

  • A 51-year-old male presented with dry cough, low-grade fever, right-sided pleural effusion, and blood eosinophilia post-CABG.
  • Symptoms and chest X-ray findings improved upon warfarin discontinuation.
  • Readministration of warfarin led to recurrent eosinophilia and contralateral pleural effusion.

Findings:

  • Warfarin was identified as the likely causative agent for the patient's eosinophilic pleurisy.
  • Extensive evaluations ruled out other specific etiologies for the observed symptoms.

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  • This case represents the first documented instance of warfarin-induced eosinophilic pleurisy.

    • Implications:

    • Clinicians should consider warfarin-induced hypersensitivity in patients with unexplained eosinophilia and pleural effusions.
    • Early recognition and discontinuation of warfarin can lead to resolution of symptoms.
    • This finding expands the known spectrum of adverse reactions associated with warfarin therapy.