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Prospects for new vaccines against tuberculosis
1Dept of Microbiology, Colorado State University, Fort Collins 80523, USA.
Trends in Microbiology
|October 1, 1995
Abstract:
The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.