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A new animal model for abdominal aortic aneurysms:initial results using a multiple-wire stent

T Whitbread1, P Birch, S Rogers

  • 1Vascular Unit, Royal Hallamshire Hospital, Sheffield, U.K.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|January 1, 1996
PubMed
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A new animal model for abdominal aortic aneurysms was developed. A Wallstent effectively reduced aneurysm size, pulsatility, and pressure, with 50% experiencing sac thrombosis.

Area of Science:

  • Biomedical Engineering
  • Vascular Surgery
  • Animal Models

Background:

  • Abdominal aortic aneurysms (AAAs) pose significant clinical challenges.
  • Developing reliable animal models is crucial for evaluating endoprostheses.
  • Existing models may not fully replicate human AAA dimensions or pulsatility.

Purpose of the Study:

  • To establish a novel animal model for studying abdominal aortic aneurysms.
  • To assess the efficacy of a specific flexible stent (Wallstent) in this AAA model.

Main Methods:

  • Created aneurysms in pigs by interposing bovine jugular vein segments into the aorta.
  • Group 1: assessed aneurysms at 6 weeks (ultrasonography, arteriography, pathology).
  • Group 2: stented aneurysms 2 weeks post-creation, assessed at 6 weeks post-stenting (ultrasonography, arteriography, pathology).

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Main Results:

  • Unstented aneurysms remained pulsatile with partial endothelialization.
  • Wallstent placement was technically successful, reducing pulsatility and diameter.
  • Sac thrombosis occurred in 50% of stented aneurysms; pulse pressure reduced in all.

Conclusions:

  • A pulsatile, non-thrombogenic aortic aneurysm model suitable for endoprosthesis evaluation was created.
  • The flexible Wallstent demonstrated effectiveness in reducing AAA pulsatility, sac pressure, and diameter.
  • Stenting achieved sac thrombosis in half of the cases, indicating potential for aneurysm exclusion.