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Macro- and microcirculatory effects of IL-15
1Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa 33612, USA.
Shock (Augusta, Ga.)
|October 1, 1995
Summary
Interleukin-15 (IL-15) significantly reduced heart rate and arterial pressure in rats, indicating potential cardiovascular impacts. This cytokine also caused arteriolar constriction by inhibiting vasodilation.
Area of Science:
- Cardiovascular Physiology
- Immunology
- Cytokine Research
Background:
- Interleukin-15 (IL-15) is a recently isolated and cloned cytokine.
- The cardiovascular effects of IL-15 have not been fully elucidated.
Purpose of the Study:
- To investigate the systemic and local cardiovascular effects of Interleukin-15 (IL-15).
Main Methods:
- Rats were anesthetized and administered varying doses of IL-15 intravenously (Group I) or topically to the cremaster muscle (Group II).
- Cardiovascular parameters (heart rate, arterial pressure) and arteriolar diameters were measured using videomicroscopy.
Main Results:
- Systemic and topical administration of IL-15 led to significant decreases in heart rate and arterial pressure.
- IL-15 caused constriction of A1 and A2 arterioles, while A3 diameters remained unchanged.
- IL-15 abolished vasodilation induced by acetylcholine and nitroprusside, indicating impaired smooth muscle relaxation.
Conclusions:
- IL-15 exerts significant systemic cardiovascular effects, including reduced heart rate and arterial pressure, suggesting a decrease in cardiac output.
- Locally, IL-15 induces arteriolar constriction by inhibiting smooth muscle vasodilation, impacting microcirculation.